AHCC (Active Hexose Correlated Compound)

AHCC (Active Hexose Correlated Compound) is a standardized extract derived from cultured Lentinula edodes (shiitake) mycelia. It's rich in alpha-glucans with a low molecular weight (about 5,000 daltons), which may enhance absorption and bioavailability compared to other mushroom polysaccharides.

AHCC has been extensively studied for its immune-modulating properties, with over 30 clinical trials examining its effects on immune function, infection resistance, and as a complementary therapy in various conditions. It's particularly noted for enhancing natural killer (NK) cell activity, a key component of innate immunity against viruses and abnormal cells.

AHCC's mechanisms of action include:

**Immune Enhancement:** - Increases natural killer (NK) cell activity and cytotoxicity - Enhances macrophage and dendritic cell function - Modulates cytokine production (increases IFN-gamma, IL-12; regulates IL-6, TNF-alpha) - Improves T-cell proliferation and function

**Antiviral Activity:** - Supports viral clearance through enhanced cell-mediated immunity - Particularly studied for HPV, influenza, and hepatitis C - May prevent viral entry and replication through immune upregulation

**Hepatoprotective Effects:** - Reduces liver enzyme elevation - Decreases oxidative stress in liver tissue - May improve liver fibrosis markers - Supports liver regeneration

The low molecular weight of AHCC's alpha-glucans allows for easier absorption in the gut and may explain its systemic immune effects.